Supplement Protocol Guides

Welcome

Steady energy is built, not bought

The basics do the heavy lifting. The right formula is the finishing touch.

Most of us want the same thing from a good day: energy that lasts from morning to evening, and focus when it counts. Supplements can help, but they work best on top of a solid routine. This guide walks you through both.

The Energy & Focus collection

Enfinity® Paraxanthine

200 mg paraxanthine: a caffeine-free stimulant. In stock, Subscribe & Save.

Caffeine 2.0

22.5 mg longer-lasting d9-caffeine. Pre-order, ships by Oct 30, 2026.

Caffeine 2.0 + L-Theanine

22.5 mg d9-caffeine + 50 mg L-theanine. Pre-order, ships by Oct 30, 2026.

Golden rule

Choose one formula per day. Never combine paraxanthine with caffeine.

The foundations

What really drives daily energy

Five levers you control every day.

Where stimulants fit

Caffeine is one of the most studied compounds for alertness and vigilance, especially when you are tired [5]. Healthy adults are generally advised to stay at or under about 400 mg of ordinary caffeine a day, and less during pregnancy [6]. But timing matters: 400 mg taken even 6 hours before bed measurably reduced sleep in one study [7]. People also differ widely in how fast they clear caffeine [8].

Formula spotlight

Enfinity® Paraxanthine

Caffeine's main metabolite, taken on its own. Caffeine-free, but still a stimulant.

Your liver converts about 80% of the caffeine you drink into paraxanthine [9], which has a slightly shorter average half-life than caffeine [10]. Small, randomized trials of Enfinity® in healthy adults found improvements on some attention, memory and reaction-time measures [11, 12]. Those trials were small and funded by the ingredient maker, so we call the evidence early but encouraging.

Enfinity® at a glance

Per capsule

200 mg Enfinity® paraxanthine

How to take

1 capsule in the morning or 30 minutes before demanding work; up to 2 per day

Cut-off

Avoid within 6 hours of bedtime

Important

Do not combine with caffeine or other stimulants. Start with half a capsule if caffeine-sensitive.

Not for

Children, pregnant or lactating women, people sensitive to caffeine

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula spotlight

Caffeine 2.0: d9-caffeine

The caffeine molecule, rebuilt with deuterium to stay active longer. Two versions, on pre-order now.

In d9-caffeine, nine hydrogen atoms are replaced with deuterium, a stable form of hydrogen, which slows the body's breakdown of the molecule. In a single-dose study of 20 adults, it produced 4 to 5 times higher total exposure than ordinary caffeine [13]; in lab tests it acted on adenosine receptors much like caffeine [14]. Both studies came from the developer, and trials on focus outcomes are still to come. L-theanine, from tea, has been studied alongside caffeine in several small trials with modest attention benefits, usually at higher doses than ours [15].

Caffeine 2.0 at a glance

How to take

1 to 4 capsules per day as needed, with or without food. Start with 1.

Daily limit

Do not exceed 90 mg of d9-caffeine (4 capsules) per day

Timing

Morning; avoid late-day doses if you are sensitive to caffeine

Not for

Children, pregnant or breastfeeding individuals, people sensitive to caffeine

Availability

Pre-order, ships by October 30, 2026

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Choosing

Choose your path: one at a time

These formulas are alternatives, not a stack. Pick the one that fits your day.

Switching between them

• One per day. If you want to try both, use them on different days, never the same day.
• Coffee days count. If you drink coffee, that day is not an Enfinity® day.
• New to all of it? Start with the lowest serving, keep it in the morning, and talk to your healthcare provider if you take medication.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Consult your healthcare provider before starting any supplement, especially if you are pregnant, breastfeeding, taking medication, or sensitive to caffeine. Not for children.

Daily rhythm

Energy habits that make it work

Good timing, water and sleep make any energy routine work better.

Your afternoon-dip toolkit

Feeling a slump around 3 p.m.? Before reaching for another stimulant, try one of these:

Fuel

Food and movement for steady energy

Simple plate-building and movement habits that help your day feel even.

Small swaps, big difference

Putting it together

A sample daily routine

Choose Path A or Path B for the day. Never both.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This sample routine is for general wellness education. Product timing should always follow the label directions. Consult your healthcare provider before starting any supplement, especially if you are pregnant, breastfeeding, taking medication, or sensitive to caffeine. Not for children.

Track it

Your 30-day checklist

Check off each habit you complete. Aim for progress, not perfection: most days, most habits.

One formula per day, within its label. Never combine Enfinity® with caffeine.

Evidence notes

How strong is the evidence?

A quick, honest read on how strong the science is for each part of this guide.

How to read the dots: ●●●● strong and consistent human evidence · ●●●○ moderate · ●●○○ early or mixed · ●○○○ mostly lab or animal research.

Worth knowing

• The basics beat the bottle. The strongest evidence in this guide is for free habits.
• Industry funding is common. The paraxanthine and d9-caffeine studies came from the companies behind the ingredients. That does not make them wrong, but independent studies matter.
• One path at a time. Paraxanthine's label says not to combine it with caffeine, so we never present these formulas as a stack.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Evidence notes

What the research suggests

The studies behind this guide, in plain language, with their limits.

1. Blume C, et al. Effects of light on human circadian rhythms, sleep and mood. Somnologie (Berl). 2019;23(3):147-156. PMID 31534436 · doi:10.1007/s11818-019-00215-x

   Review: light, especially in the morning, is the main signal that sets the body clock; bright evening light can delay sleep.

2. Watson NF, et al. Recommended Amount of Sleep for a Healthy Adult: A Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society. J Clin Sleep Med. 2015;11(6):591-2. PMID 25979105 · doi:10.5664/jcsm.4758

   Expert consensus: adults should regularly sleep 7 or more hours per night.

3. Armstrong LE, et al. Mild dehydration affects mood in healthy young women. J Nutr. 2012;142(2):382-8. PMID 22190027 · doi:10.3945/jn.111.142000

   Mild dehydration was linked with lower mood and concentration in 25 young women.

4. Piercy KL, et al. The Physical Activity Guidelines for Americans. JAMA. 2018;320(19):2020-2028. PMID 30418471 · doi:10.1001/jama.2018.14854

   U.S. guidance: 150+ minutes of moderate activity weekly plus muscle-strengthening on 2+ days.

5. McLellan TM, et al. A review of caffeine's effects on cognitive, physical and occupational performance. Neurosci Biobehav Rev. 2016;71:294-312. PMID 27612937 · doi:10.1016/j.neubiorev.2016.09.001

   Review: moderate caffeine reliably supports alertness and vigilance, especially when tired.

6. Wikoff D, et al. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food Chem Toxicol. 2017;109(Pt 1):585-648. PMID 28438661 · doi:10.1016/j.fct.2017.04.002

   Large systematic review: up to 400 mg/day of caffeine was not linked to adverse effects in healthy adults (lower for pregnancy and youth).

7. Drake C, et al. Caffeine effects on sleep taken 0, 3, or 6 hours before going to bed. J Clin Sleep Med. 2013;9(11):1195-200. PMID 24235903 · doi:10.5664/jcsm.3170

   400 mg caffeine taken even 6 hours before bed reduced sleep. Studied caffeine, not paraxanthine or d9-caffeine.

8. Nehlig A. Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption. Pharmacol Rev. 2018;70(2):384-411. PMID 29514871 · doi:10.1124/pr.117.014407

   Review: genetics, pregnancy, smoking and some medications change how fast people clear caffeine.

9. Lelo A, et al. Quantitative assessment of caffeine partial clearances in man. Br J Clin Pharmacol. 1986;22(2):183-6. PMID 3756066 · doi:10.1111/j.1365-2125.1986.tb05247.x

   About 80% of caffeine was converted to paraxanthine in a small group of healthy adults.

10. Lelo A, et al. Comparative pharmacokinetics of caffeine and its primary demethylated metabolites paraxanthine, theobromine and theophylline in man. Br J Clin Pharmacol. 1986;22(2):177-82. PMID 3756065 · doi:10.1111/j.1365-2125.1986.tb05246.x

    Six healthy men: average half-life about 3.1 h for paraxanthine vs 4.1 h for caffeine. Very small study.

11. Yoo C, et al. Acute Paraxanthine Ingestion Improves Cognition and Short-Term Memory and Helps Sustain Attention in a Double-Blind, Placebo-Controlled, Crossover Trial. Nutrients. 2021;13(11). PMID 34836235 · doi:10.3390/nu13113980

    13 healthy adults; improvements on some cognitive measures vs placebo. Small and funded by the ingredient maker.

12. Xing D, et al. Dose-Response of Paraxanthine on Cognitive Function: A Double Blind, Placebo Controlled, Crossover Trial. Nutrients. 2021;13(12). PMID 34960030 · doi:10.3390/nu13124478

    12 healthy adults over 7 days; some cognitive benefits, no clinically significant side effects reported. Small, industry-funded.

13. Sherman MM, et al. A double-blind, randomized, two-part, two-period crossover study to evaluate the pharmacokinetics of caffeine versus d9-caffeine in healthy subjects. Regul Toxicol Pharmacol. 2022;133:105194. PMID 35690181 · doi:10.1016/j.yrtph.2022.105194

    20 healthy adults, single doses: d9-caffeine gave 4 to 5 times higher total exposure than regular caffeine, with far less exposure to caffeine's metabolites. Both well tolerated. Run by the ingredient developer.

14. Parente RM, et al. Pharmacokinetic, pharmacological, and genotoxic evaluation of deuterated caffeine. Food Chem Toxicol. 2022;160:112774. PMID 34974129 · doi:10.1016/j.fct.2021.112774

    Lab and rat studies: d9-caffeine was not genotoxic, stayed in the body longer in rats, and acted on adenosine receptors like caffeine. Industry-funded, no human outcomes.

15. Camfield DA, et al. Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: a systematic review and meta-analysis. Nutr Rev. 2014;72(8):507-22. PMID 24946991 · doi:10.1111/nure.12120

    Meta-analysis of 11 small trials: moderate short-term effects on alertness and attention for caffeine plus L-theanine.

Studies are cited to explain the science of ingredients and habits. They are not claims that any product will produce a specific result. Individual results vary. Every reference above is a PubMed record, listed with its PMID.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Welcome

Meet Enfinity® Paraxanthine

Focused energy, built on the molecule your body already makes from coffee.

When you drink coffee, your liver turns most of the caffeine into a compound called paraxanthine. Enfinity® Paraxanthine gives you that compound directly, in a simple vegan capsule. We built this guide so you can use it well: what to expect, how to time it, and the everyday habits that make focused energy work.

At a glance

Per capsule

200 mg Enfinity® paraxanthine (the amount used in published research)

Serving

1 capsule; up to 2 per day

When

Morning, or 30 minutes before demanding work

Stimulant note

Caffeine-free, but paraxanthine is a stimulant. Do not combine with caffeine or other stimulants.

Diet

Vegan, gluten-free, non-GMO; 30 capsules per bottle

The science

How paraxanthine works

The compound your body makes from caffeine, taken on its own.

From coffee to paraxanthine

Caffeine is broken down in the liver into three main compounds. In a classic study in healthy adults, roughly 80% became paraxanthine, with smaller amounts becoming theobromine and theophylline [1]. When you take paraxanthine directly, you skip that step.

In a small study of six healthy men, paraxanthine had an average half-life of about 3.1 hours compared with 4.1 hours for caffeine [2]. People vary a lot in how fast they clear these compounds, based on genetics, pregnancy, smoking and some medications [3], so your own timing may differ.

What the early research shows

Small, randomized, placebo-controlled trials in healthy adults have tested Enfinity® paraxanthine. Participants did better than placebo on some measures of attention, short-term memory and reaction time [4, 5], and one trial in trained runners tested mental tasks after a 10 km run [6]. These studies were small and funded by the ingredient maker, so we see them as promising, not final.

How it may fit your day*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Practical how-to

How to take it

Five simple steps, straight from the label, to start well.

1. Start low if you are sensitive. If caffeine tends to make you jittery, begin with half a capsule for a few days.
2. Take it early. One capsule in the morning, or about 30 minutes before demanding work.
3. Mind the cut-off. Avoid taking it within 6 hours of bedtime.
4. Stay within the label. Up to 2 capsules per day. More is not better.
5. Keep it solo. Paraxanthine is a stimulant. Do not combine it with caffeine (coffee, energy drinks, pre-workout) or other stimulants.

Who it is for, and who should skip it

• A good fit for: people doing cognitively demanding work or study, and people who have stepped away from caffeine but still want morning focus support.*
• Not for: children, pregnant or lactating women, or people sensitive to caffeine. Check with your healthcare provider first if you take medication or have a health condition.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Practical how-to

Moving over from coffee

The label says do not combine paraxanthine with caffeine. Here is how to make that easy.

Keep the ritual, swap the cup

A gentle switch-over plan

1. Days 1 to 3: notice. Write down every caffeine source you have: coffee, tea, soda, energy drinks, pre-workout, chocolate.
2. Days 4 to 10: taper. Cut back gradually, for example half-caf, then decaf. Some people notice headaches or tiredness when they stop caffeine suddenly, so going slowly can feel easier.
3. Day 11 onward: switch. On days you take Enfinity®, skip caffeinated drinks entirely and use your swap cup instead.
4. Check labels. Caffeine hides in pre-workouts, some sodas, "energy" waters and some pain relievers. Read labels.

Daily rhythm

Energy habits that make it work

Good timing, water and sleep make any energy routine work better.

Your afternoon-dip toolkit

Feeling a slump around 3 p.m.? Before reaching for another stimulant, try one of these:

Putting it together

A sample daily routine

A template, not a rulebook. Shift the times to fit your life.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This sample routine is for general wellness education. Product timing should always follow the label directions. Consult your healthcare provider before starting any supplement, especially if you are pregnant, nursing, taking medication, or sensitive to caffeine. Not for children.

Track it

Your 30-day checklist

Check off each habit you complete. Aim for progress, not perfection: most days, most habits.

Follow the label directions.

Evidence notes

How strong is the evidence?

A quick, honest read on how strong the science is for each part of this guide.

How to read the dots: ●●●● strong and consistent human evidence · ●●●○ moderate · ●●○○ early or mixed · ●○○○ mostly lab or animal research.

Worth knowing

• Industry funding is common in this field. It does not make a study wrong, but independent replication matters, and we will update this guide as more arrives.
• Small studies, short time frames. Most trials ran from a single day to about a week, with 12 to 21 people.
• Your response is personal. Genetics and medications change how people process these compounds [3]. Start low and adjust within the label.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Evidence notes

What the research suggests

The studies behind this guide, in plain language, with their limits.

1. Lelo A, et al. Quantitative assessment of caffeine partial clearances in man. Br J Clin Pharmacol. 1986;22(2):183-6. PMID 3756066 · doi:10.1111/j.1365-2125.1986.tb05247.x

   About 80% of caffeine was converted to paraxanthine in a small group of healthy adults.

2. Lelo A, et al. Comparative pharmacokinetics of caffeine and its primary demethylated metabolites paraxanthine, theobromine and theophylline in man. Br J Clin Pharmacol. 1986;22(2):177-82. PMID 3756065 · doi:10.1111/j.1365-2125.1986.tb05246.x

   Six healthy men: average half-life about 3.1 h for paraxanthine vs 4.1 h for caffeine. Very small study.

3. Nehlig A. Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption. Pharmacol Rev. 2018;70(2):384-411. PMID 29514871 · doi:10.1124/pr.117.014407

   Review: genetics, pregnancy, smoking and some medications change how fast people clear caffeine.

4. Yoo C, et al. Acute Paraxanthine Ingestion Improves Cognition and Short-Term Memory and Helps Sustain Attention in a Double-Blind, Placebo-Controlled, Crossover Trial. Nutrients. 2021;13(11). PMID 34836235 · doi:10.3390/nu13113980

   13 healthy adults; improvements on some cognitive measures vs placebo. Small and funded by the ingredient maker.

5. Xing D, et al. Dose-Response of Paraxanthine on Cognitive Function: A Double Blind, Placebo Controlled, Crossover Trial. Nutrients. 2021;13(12). PMID 34960030 · doi:10.3390/nu13124478

   12 healthy adults over 7 days; some cognitive benefits, no clinically significant side effects reported. Small, industry-funded.

6. Yoo C, et al. Paraxanthine provides greater improvement in cognitive function than caffeine after performing a 10-km run. J Int Soc Sports Nutr. 2024;21(1):2352779. PMID 38725238 · doi:10.1080/15502783.2024.2352779

   12 trained runners; compared paraxanthine, caffeine and placebo on post-run mental tasks. Small, industry-funded.

7. Blume C, et al. Effects of light on human circadian rhythms, sleep and mood. Somnologie (Berl). 2019;23(3):147-156. PMID 31534436 · doi:10.1007/s11818-019-00215-x

   Review: light, especially in the morning, is the main signal that sets the body clock; bright evening light can delay sleep.

8. Drake C, et al. Caffeine effects on sleep taken 0, 3, or 6 hours before going to bed. J Clin Sleep Med. 2013;9(11):1195-200. PMID 24235903 · doi:10.5664/jcsm.3170

   400 mg caffeine taken even 6 hours before bed reduced sleep. Studied caffeine, not paraxanthine or d9-caffeine.

9. Armstrong LE, et al. Mild dehydration affects mood in healthy young women. J Nutr. 2012;142(2):382-8. PMID 22190027 · doi:10.3945/jn.111.142000

   Mild dehydration was linked with lower mood and concentration in 25 young women.

10. Watson NF, et al. Recommended Amount of Sleep for a Healthy Adult: A Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society. J Clin Sleep Med. 2015;11(6):591-2. PMID 25979105 · doi:10.5664/jcsm.4758

    Expert consensus: adults should regularly sleep 7 or more hours per night.

11. Bingol Diedhiou A, et al. Comparative effects of caffeine and paraxanthine on rowing performance and sleep quality: a randomized crossover study. J Int Soc Sports Nutr. 2026;23(1):2650339. PMID 41918248 · doi:10.1080/15502783.2026.2650339

    14 university rowers; paraxanthine alone showed more favorable self-reported sleep than caffeine. Small, subjective sleep measures, no reported industry conflicts.

12. Purpura M, et al. An assessment of mutagenicity, genotoxicity, acute-, subacute and subchronic oral toxicity of paraxanthine (1,7-dimethylxanthine). Food Chem Toxicol. 2021;158:112579. PMID 34597720 · doi:10.1016/j.fct.2021.112579

    Lab and rat safety studies of Enfinity paraxanthine: no toxic effects seen at the doses tested. Animal data, industry authors.

13. Gross KN, et al. A Dose-Response Study to Examine Paraxanthine's Impact on Energy Expenditure, Hunger, Appetite, and Lipolysis. J Diet Suppl. 2024;21(5):608-632. PMID 38745415 · doi:10.1080/19390211.2024.2351222

    21 adults, single doses of 100 to 300 mg; 200 mg raised energy expenditure vs placebo, blood pressure unchanged. Industry co-authors.

Studies are cited to explain the science of ingredients and habits. They are not claims that any product will produce a specific result. Individual results vary. Every reference above is a PubMed record, listed with its PMID.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Welcome

Meet Caffeine 2.0

The same caffeine molecule you know, rebuilt to stay active longer.

Caffeine 2.0 uses Deura9® d9-caffeine, a patented form of caffeine designed to be cleared more slowly by the body. This guide shows you how to use it well and build the daily habits that make focused energy work.

At a glance

Per capsule

22.5 mg Deura9® d9-caffeine

Serving

1 capsule; 1 to 4 per day as needed, with or without food

Daily limit

Do not exceed 90 mg of d9-caffeine (4 capsules) per day

Stimulant note

Count it as caffeine when tracking your daily intake

Availability

Pre-order. Ships by October 30, 2026

The science

How d9-caffeine works

Same molecule, slightly heavier, cleared more slowly.

What "d9" means

Your liver clears regular caffeine within hours, which is why the lift fades. In d9-caffeine, nine hydrogen atoms are replaced with deuterium, a stable, naturally occurring form of hydrogen. Those slightly stronger bonds slow the enzymes that break caffeine down. In lab tests, d9-caffeine acted on the brain's adenosine receptors with similar potency to caffeine, and it was not genotoxic [2].

In a randomized crossover study of 20 healthy adults, single doses of d9-caffeine produced 4 to 5 times higher total exposure than an equal dose of regular caffeine, with much less exposure to caffeine's breakdown products. Both were well tolerated [1]. That is why each capsule holds just 22.5 mg, and why one capsule is the right place to start.

How it may fit your day*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Practical how-to

How to take it

Five simple steps, straight from the label, to start well.

1. Start with one. d9-caffeine is more potent per milligram and lasts longer than ordinary caffeine, so begin with a single capsule.
2. Take it early. Morning or the start of your work block, with or without food. Avoid late-day doses if you are sensitive to caffeine.
3. Wait before adding more. Give a capsule time to work before deciding on a second. Use 1 to 4 capsules per day, only as needed.
4. Respect the daily limit. Never exceed 90 mg of d9-caffeine (4 capsules) in a day.
5. Count it as caffeine. Add it to your coffee, tea, soda and pre-workout total. Do not pair it with Enfinity® Paraxanthine, whose label says not to combine with caffeine.

Who it is for, and who should skip it

• A good fit for: long work days, study sessions and shifts, and people who want steady energy without re-dosing caffeine all afternoon.*
• Not for: children, pregnant or breastfeeding individuals, or people sensitive to caffeine. Check with your healthcare provider first if you take medication or have a health condition.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Practical how-to

Find your dose and timing

A one-week experiment to learn what works for you, inside the label limits.

Do not use "coffee math"

Caffeine guidance for healthy adults, such as the often-cited 400 mg per day, was built on ordinary caffeine [3]. d9-caffeine produces much more exposure per milligram [1], so follow its label: 1 to 4 capsules a day, never more than 90 mg of d9-caffeine. People also differ widely in how fast they process caffeine [4].

Your 7-day dose diary

Reading your diary

• Focus good, sleep good? You have found your routine. Keep it consistent.
• Sleep slipping? Move your capsule earlier or take fewer, and check for hidden caffeine.
• Want more lift? Before adding a capsule, check the basics in your energy habits: daylight, water and sleep.

Daily rhythm

Energy habits that make it work

Good timing, water and sleep make any energy routine work better.

Your afternoon-dip toolkit

Feeling a slump around 3 p.m.? Before reaching for another stimulant, try one of these:

Putting it together

A sample daily routine

A template, not a rulebook. Shift the times to fit your life.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This sample routine is for general wellness education. Product timing should always follow the label directions. Consult your healthcare provider before starting any supplement, especially if you are pregnant, breastfeeding, taking medication, or sensitive to caffeine. Not for children.

Track it

Your 30-day checklist

Check off each habit you complete. Aim for progress, not perfection: most days, most habits.

Follow the label directions: 1 to 4 capsules per day as needed, never more than 90 mg of d9-caffeine.

Evidence notes

How strong is the evidence?

A quick, honest read on how strong the science is for each part of this guide.

How to read the dots: ●●●● strong and consistent human evidence · ●●●○ moderate · ●●○○ early or mixed · ●○○○ mostly lab or animal research.

Worth knowing

• This is a new ingredient. The published human research is about how d9-caffeine moves through the body, not yet about how people feel or perform on it. We will update this guide as studies arrive.
• The caffeine evidence applies by close relation, not proof. d9-caffeine works on the same receptors as caffeine [2], so caffeine research is a reasonable guide, but not a substitute for direct trials.
• Start low. More exposure per milligram means a small dose goes a long way.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Evidence notes

What the research suggests

The studies behind this guide, in plain language, with their limits.

1. Sherman MM, et al. A double-blind, randomized, two-part, two-period crossover study to evaluate the pharmacokinetics of caffeine versus d9-caffeine in healthy subjects. Regul Toxicol Pharmacol. 2022;133:105194. PMID 35690181 · doi:10.1016/j.yrtph.2022.105194

   20 healthy adults, single doses: d9-caffeine gave 4 to 5 times higher total exposure than regular caffeine, with far less exposure to caffeine's metabolites. Both well tolerated. Run by the ingredient developer.

2. Parente RM, et al. Pharmacokinetic, pharmacological, and genotoxic evaluation of deuterated caffeine. Food Chem Toxicol. 2022;160:112774. PMID 34974129 · doi:10.1016/j.fct.2021.112774

   Lab and rat studies: d9-caffeine was not genotoxic, stayed in the body longer in rats, and acted on adenosine receptors like caffeine. Industry-funded, no human outcomes.

3. Wikoff D, et al. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food Chem Toxicol. 2017;109(Pt 1):585-648. PMID 28438661 · doi:10.1016/j.fct.2017.04.002

   Large systematic review: up to 400 mg/day of caffeine was not linked to adverse effects in healthy adults (lower for pregnancy and youth).

4. Nehlig A. Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption. Pharmacol Rev. 2018;70(2):384-411. PMID 29514871 · doi:10.1124/pr.117.014407

   Review: genetics, pregnancy, smoking and some medications change how fast people clear caffeine.

5. Blume C, et al. Effects of light on human circadian rhythms, sleep and mood. Somnologie (Berl). 2019;23(3):147-156. PMID 31534436 · doi:10.1007/s11818-019-00215-x

   Review: light, especially in the morning, is the main signal that sets the body clock; bright evening light can delay sleep.

6. Drake C, et al. Caffeine effects on sleep taken 0, 3, or 6 hours before going to bed. J Clin Sleep Med. 2013;9(11):1195-200. PMID 24235903 · doi:10.5664/jcsm.3170

   400 mg caffeine taken even 6 hours before bed reduced sleep. Studied caffeine, not paraxanthine or d9-caffeine.

7. Armstrong LE, et al. Mild dehydration affects mood in healthy young women. J Nutr. 2012;142(2):382-8. PMID 22190027 · doi:10.3945/jn.111.142000

   Mild dehydration was linked with lower mood and concentration in 25 young women.

8. Watson NF, et al. Recommended Amount of Sleep for a Healthy Adult: A Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society. J Clin Sleep Med. 2015;11(6):591-2. PMID 25979105 · doi:10.5664/jcsm.4758

   Expert consensus: adults should regularly sleep 7 or more hours per night.

9. McLellan TM, et al. A review of caffeine's effects on cognitive, physical and occupational performance. Neurosci Biobehav Rev. 2016;71:294-312. PMID 27612937 · doi:10.1016/j.neubiorev.2016.09.001

   Review: moderate caffeine reliably supports alertness and vigilance, especially when tired.

Studies are cited to explain the science of ingredients and habits. They are not claims that any product will produce a specific result. Individual results vary. Every reference above is a PubMed record, listed with its PMID.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Welcome

Meet Caffeine 2.0 + L-Theanine

Long-lasting caffeine, paired with a calm-minded amino acid from tea.

Caffeine 2.0 + L-Theanine uses Deura9® d9-caffeine, a patented form of caffeine designed to be cleared more slowly by the body. We paired it with L-theanine, an amino acid found naturally in tea leaves. This guide shows you how to use it well and build the daily habits that make focused energy work.

At a glance

Per capsule

22.5 mg Deura9® d9-caffeine + 50 mg L-theanine

Serving

1 capsule; 1 to 4 per day as needed, with or without food

Daily limit

Do not exceed 90 mg of d9-caffeine (4 capsules) per day

Stimulant note

Count it as caffeine when tracking your daily intake

Availability

Pre-order. Ships by October 30, 2026

The science

How d9-caffeine works with L-theanine

Same molecule, slightly heavier, cleared more slowly.

What "d9" means

Your liver clears regular caffeine within hours, which is why the lift fades. In d9-caffeine, nine hydrogen atoms are replaced with deuterium, a stable, naturally occurring form of hydrogen. Those slightly stronger bonds slow the enzymes that break caffeine down. In lab tests, d9-caffeine acted on the brain's adenosine receptors with similar potency to caffeine, and it was not genotoxic [2].

In a randomized crossover study of 20 healthy adults, single doses of d9-caffeine produced 4 to 5 times higher total exposure than an equal dose of regular caffeine, with much less exposure to caffeine's breakdown products. Both were well tolerated [1]. That is why each capsule holds just 22.5 mg, and why one capsule is the right place to start.

Why L-theanine?

L-theanine is an amino acid found in tea. Several small trials found that caffeine and L-theanine together improved some measures of attention and alertness [3, 4, 5], and a meta-analysis found moderate short-term effects for the pair [6]. Many of those studies used more L-theanine (about 100 to 250 mg) than our 50 mg per capsule.

How it may fit your day*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Practical how-to

How to take it

Five simple steps, straight from the label, to start well.

1. Start with one. d9-caffeine is more potent per milligram and lasts longer than ordinary caffeine, so begin with a single capsule.
2. Take it early. Morning or the start of your work block, with or without food. Avoid late-day doses if you are sensitive to caffeine.
3. Wait before adding more. Give a capsule time to work before deciding on a second. Use 1 to 4 capsules per day, only as needed.
4. Respect the daily limit. Never exceed 90 mg of d9-caffeine (4 capsules) in a day.
5. Count it as caffeine. Add it to your coffee, tea, soda and pre-workout total. Do not pair it with Enfinity® Paraxanthine, whose label says not to combine with caffeine.

Who it is for, and who should skip it

• A good fit for: long work days, study sessions and shifts, and people who want steady energy without re-dosing caffeine all afternoon.*
• Not for: children, pregnant or breastfeeding individuals, or people sensitive to caffeine. Check with your healthcare provider first if you take medication or have a health condition.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Practical how-to

Find your dose and timing

A one-week experiment to learn what works for you, inside the label limits.

Do not use "coffee math"

Caffeine guidance for healthy adults, such as the often-cited 400 mg per day, was built on ordinary caffeine [7]. d9-caffeine produces much more exposure per milligram [1], so follow its label: 1 to 4 capsules a day, never more than 90 mg of d9-caffeine. People also differ widely in how fast they process caffeine [8].

Your 7-day dose diary

Reading your diary

• Focus good, sleep good? You have found your routine. Keep it consistent.
• Sleep slipping? Move your capsule earlier or take fewer, and check for hidden caffeine.
• Want more lift? Before adding a capsule, check the basics in your energy habits: daylight, water and sleep.

Daily rhythm

Energy habits that make it work

Good timing, water and sleep make any energy routine work better.

Your afternoon-dip toolkit

Feeling a slump around 3 p.m.? Before reaching for another stimulant, try one of these:

Putting it together

A sample daily routine

A template, not a rulebook. Shift the times to fit your life.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This sample routine is for general wellness education. Product timing should always follow the label directions. Consult your healthcare provider before starting any supplement, especially if you are pregnant, breastfeeding, taking medication, or sensitive to caffeine. Not for children.

Track it

Your 30-day checklist

Check off each habit you complete. Aim for progress, not perfection: most days, most habits.

Follow the label directions: 1 to 4 capsules per day as needed, never more than 90 mg of d9-caffeine.

Evidence notes

How strong is the evidence?

A quick, honest read on how strong the science is for each part of this guide.

How to read the dots: ●●●● strong and consistent human evidence · ●●●○ moderate · ●●○○ early or mixed · ●○○○ mostly lab or animal research.

Worth knowing

• This is a new ingredient. The published human research is about how d9-caffeine moves through the body, not yet about how people feel or perform on it. We will update this guide as studies arrive.
• The caffeine evidence applies by close relation, not proof. d9-caffeine works on the same receptors as caffeine [2], so caffeine research is a reasonable guide, but not a substitute for direct trials.
• Start low. More exposure per milligram means a small dose goes a long way.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Evidence notes

What the research suggests

The studies behind this guide, in plain language, with their limits.

1. Sherman MM, et al. A double-blind, randomized, two-part, two-period crossover study to evaluate the pharmacokinetics of caffeine versus d9-caffeine in healthy subjects. Regul Toxicol Pharmacol. 2022;133:105194. PMID 35690181 · doi:10.1016/j.yrtph.2022.105194

   20 healthy adults, single doses: d9-caffeine gave 4 to 5 times higher total exposure than regular caffeine, with far less exposure to caffeine's metabolites. Both well tolerated. Run by the ingredient developer.

2. Parente RM, et al. Pharmacokinetic, pharmacological, and genotoxic evaluation of deuterated caffeine. Food Chem Toxicol. 2022;160:112774. PMID 34974129 · doi:10.1016/j.fct.2021.112774

   Lab and rat studies: d9-caffeine was not genotoxic, stayed in the body longer in rats, and acted on adenosine receptors like caffeine. Industry-funded, no human outcomes.

3. Owen GN, et al. The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutr Neurosci. 2008;11(4):193-8. PMID 18681988 · doi:10.1179/147683008X301513

   27 adults: caffeine plus L-theanine improved some attention measures vs placebo. Authors from a tea company.

4. Haskell CF, et al. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol Psychol. 2008;77(2):113-22. PMID 18006208 · doi:10.1016/j.biopsycho.2007.09.008

   27 adults: the combination improved some speed, accuracy and alertness measures. University study.

5. Giesbrecht T, et al. The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutr Neurosci. 2010;13(6):283-90. PMID 21040626 · doi:10.1179/147683010X12611460764840

   44 young adults: combination improved attention-switching accuracy and alertness. Authors from a tea company.

6. Camfield DA, et al. Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: a systematic review and meta-analysis. Nutr Rev. 2014;72(8):507-22. PMID 24946991 · doi:10.1111/nure.12120

   Meta-analysis of 11 small trials: moderate short-term effects on alertness and attention for caffeine plus L-theanine.

7. Wikoff D, et al. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food Chem Toxicol. 2017;109(Pt 1):585-648. PMID 28438661 · doi:10.1016/j.fct.2017.04.002

   Large systematic review: up to 400 mg/day of caffeine was not linked to adverse effects in healthy adults (lower for pregnancy and youth).

8. Nehlig A. Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption. Pharmacol Rev. 2018;70(2):384-411. PMID 29514871 · doi:10.1124/pr.117.014407

   Review: genetics, pregnancy, smoking and some medications change how fast people clear caffeine.

9. Blume C, et al. Effects of light on human circadian rhythms, sleep and mood. Somnologie (Berl). 2019;23(3):147-156. PMID 31534436 · doi:10.1007/s11818-019-00215-x

   Review: light, especially in the morning, is the main signal that sets the body clock; bright evening light can delay sleep.

10. Drake C, et al. Caffeine effects on sleep taken 0, 3, or 6 hours before going to bed. J Clin Sleep Med. 2013;9(11):1195-200. PMID 24235903 · doi:10.5664/jcsm.3170

    400 mg caffeine taken even 6 hours before bed reduced sleep. Studied caffeine, not paraxanthine or d9-caffeine.

11. Armstrong LE, et al. Mild dehydration affects mood in healthy young women. J Nutr. 2012;142(2):382-8. PMID 22190027 · doi:10.3945/jn.111.142000

    Mild dehydration was linked with lower mood and concentration in 25 young women.

12. Watson NF, et al. Recommended Amount of Sleep for a Healthy Adult: A Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society. J Clin Sleep Med. 2015;11(6):591-2. PMID 25979105 · doi:10.5664/jcsm.4758

    Expert consensus: adults should regularly sleep 7 or more hours per night.

13. McLellan TM, et al. A review of caffeine's effects on cognitive, physical and occupational performance. Neurosci Biobehav Rev. 2016;71:294-312. PMID 27612937 · doi:10.1016/j.neubiorev.2016.09.001

    Review: moderate caffeine reliably supports alertness and vigilance, especially when tired.

14. Cotter J, et al. Effects of L-theanine on cognition, mood and sleep: evidence from human trials. Front Nutr. 2026;13:1922819. PMID 42761839 · doi:10.3389/fnut.2026.1922819

    2026 mini-review: small but real effects on attention, especially with caffeine; generally well tolerated. Authors work for a company that sells L-theanine products.

Studies are cited to explain the science of ingredients and habits. They are not claims that any product will produce a specific result. Individual results vary. Every reference above is a PubMed record, listed with its PMID.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Welcome

A happier gut, one habit at a time

Food first, rhythm second, and smart support on top.

Trillions of microbes live in your large intestine, and what you eat, how you sleep and how you move all shape them. This guide covers the science in plain language, the food and habits with the best evidence, and how our two gut formulas fit in.

The Gut Health collection

Tributyrin Post-Biotic

300 mg active tributyrin per capsule: a stable, odorless form of butyrate

Akkermansia Probiotic

1 billion AFU live, microencapsulated Akkermansia muciniphila per capsule

How to take

Each: 1 capsule daily with food, up to 2 per day

Give it time

At least 4 to 8 weeks of consistent use

The foundations

How your gut microbiome works

Microbes, mucus and the food that connects them.

Three ideas worth knowing

• Fiber is microbe food. Gut bacteria ferment fiber into short-chain fatty acids, including butyrate [1].
• Butyrate fuels your gut lining. In lab studies of human colon cells, butyrate supplied most of their energy when available [2], and it has many roles in the colon [5].
• Variety matters. People who ate 30 or more different plants a week had more diverse gut microbes than those who ate 10 or fewer [6], and a fermented-food diet raised diversity in a 10-week trial [7].

Formula spotlight

Tributyrin Post-Biotic

Butyrate support, designed to arrive further along the digestive tract.

Plain butyrate salts are absorbed early and smell like rancid butter. Tributyrin is three butyrate molecules on a glycerol backbone, released by digestive lipase. In a lab simulation of human digestion, about half of a tributyrin dose stayed intact into the colon stage [8]. Research on tributyrin itself is still mostly in the lab and in animals [9], so we treat it as promising support on top of a fiber-rich diet.

Tributyrin at a glance

Per capsule

550 mg tributyrin 55%, yielding 300 mg active tributyrin

How to take

1 capsule daily with food, up to 2 per day

Give it time

At least 4 to 8 weeks

Diet

Vegan, gluten-free, non-GMO, dairy-free, nut-free; made in the USA

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula spotlight

Akkermansia Probiotic

The gut-friendly bacterium most probiotics leave out.

Akkermansia muciniphila lives in the mucus layer lining your gut and supports normal mucus turnover.* It is hard to grow, so it is counted in AFU (active fluorescent units) rather than CFU. In a small pilot trial, 32 adults with overweight took live or pasteurized Akkermansia for 3 months, and both were safe and well tolerated [10]. Research in healthy adults is still young [11].

Akkermansia at a glance

Per capsule

Akkermansia muciniphila, 1 billion AFU, microencapsulated

How to take

1 capsule daily with food, up to 2 per day

Storage

Room temperature; no refrigeration

Diet

Vegetarian, gluten-free, dairy-free, nut-free

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Combining

Better together: probiotic, postbiotic, plants

Two formulas, one plate, and a routine you can keep.

There is an interesting lab hint here, too: in a simulated human gut model, three weeks of tributyrin raised butyrate levels and the abundance of several microbes, including Akkermansia [8]. That was a lab model funded by a tributyrin supplier, not a human trial, so we share it as curiosity, not proof.

How to combine them

1. Same meal, every day. Take one capsule of each with breakfast or lunch.
2. Start one at a time if you like. Begin with one formula for a week, then add the other, so you can notice how each feels.
3. Feed the team. Add fiber, color and a fermented food daily (see the food list).
4. Judge it in weeks. Give your routine at least 4 to 8 weeks before deciding how it is working.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Consult your healthcare provider before starting any supplement, especially if you are pregnant, nursing, taking medication, immunocompromised, or managing a digestive or other health condition.

Food first

Feed your gut: fiber and polyphenols

Supplements work best on top of a plant-rich plate.

Your gut microbes depend on what reaches them. Fiber is their main food, and they turn it into short-chain fatty acids like butyrate [1]. Polyphenols, the colorful compounds in berries, tea and cocoa, also reach the colon, where microbes and polyphenols interact in both directions [4]. Fermented foods add variety: in a 10-week diet study, eating more fermented foods increased gut microbiome diversity [7].

Simple ways to start

• Add, don't subtract. Add one fiber food to a meal you already eat: beans in a salad, berries on oats, flax in a smoothie.
• Go slow. Increase fiber gradually over a few weeks and drink extra water as you do.
• Count your plants. In a large citizen-science study, people eating 30+ different plants a week had more diverse gut microbes than those eating 10 or fewer [6]. Fruits, vegetables, grains, legumes, nuts, seeds and herbs all count.

Daily rhythm

Gut-friendly daily habits

Your gut likes routine. These habits give it a predictable day.

Your weekly plant-count challenge

Each week, tally the different plants you eat. Herbs, spices, nuts and seeds count. Try to beat last week's number.

Putting it together

A sample daily routine

A template, not a rulebook. Shift the times to fit your life.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This sample routine is for general wellness education. Product timing should always follow the label directions. Consult your healthcare provider before starting any supplement, especially if you are pregnant, nursing, taking medication, immunocompromised, or managing a digestive or other health condition.

Track it

Your 30-day checklist

Check off each habit you complete. Aim for progress, not perfection: most days, most habits.

Follow the label directions for each product. Give it at least 4 to 8 weeks.

Evidence notes

How strong is the evidence?

A quick, honest read on how strong the science is for each part of this guide.

How to read the dots: ●●●● strong and consistent human evidence · ●●●○ moderate · ●●○○ early or mixed · ●○○○ mostly lab or animal research.

Worth knowing

• Most tributyrin research is animal or lab-based, and most Akkermansia trials are small. We are excited by both, and honest that more human research is needed.
• Mechanism is not the same as outcome. Knowing how butyrate or Akkermansia work does not guarantee a specific result for you.
• Food has the strongest human evidence here. Fiber, plant variety and fermented foods are the foundation.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Evidence notes

What the research suggests

The studies behind this guide, in plain language, with their limits.

1. Koh A, et al. From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites. Cell. 2016;165(6):1332-1345. PMID 27259147 · doi:10.1016/j.cell.2016.05.041

   Review of how gut microbes turn fiber into short-chain fatty acids such as butyrate.

2. Roediger WE. Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Gut. 1980;21(9):793-8. PMID 7429343 · doi:10.1136/gut.21.9.793

   Lab study of isolated human colon cells: butyrate was their main fuel when available.

3. Derrien M, et al. Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium. Int J Syst Evol Microbiol. 2004;54(Pt 5):1469-1476. PMID 15388697 · doi:10.1099/ijs.0.02873-0

   The original description of Akkermansia muciniphila, a mucin-degrading bacterium isolated from human stool.

4. Cardona F, et al. Benefits of polyphenols on gut microbiota and implications in human health. J Nutr Biochem. 2013;24(8):1415-22. PMID 23849454 · doi:10.1016/j.jnutbio.2013.05.001

   Review: gut microbes and dietary polyphenols interact in both directions. Human data still limited.

5. Hamer HM, et al. Review article: the role of butyrate on colonic function. Aliment Pharmacol Ther. 2008;27(2):104-19. PMID 17973645 · doi:10.1111/j.1365-2036.2007.03562.x

   Review of butyrate's roles in the colon, from fuel for colon cells to the gut barrier.

6. McDonald D, et al. American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems. 2018;3(3). PMID 29795809 · doi:10.1128/mSystems.00031-18

   Citizen-science study: people eating 30+ different plants a week had more diverse gut microbes than those eating 10 or fewer. Observational.

7. Wastyk HC, et al. Gut-microbiota-targeted diets modulate human immune status. Cell. 2021;184(16):4137-4153.e14. PMID 34256014 · doi:10.1016/j.cell.2021.06.019

   Healthy adults: a high-fermented-food diet steadily increased microbiome diversity over 10 weeks. 18 people per group.

8. Duysburgh C, et al. Tributyrin (CoreBiome®) enhances butyrate levels and modulates the gut microbiota, barrier function, and immune response in vitro. Front Nutr. 2025;12:1712993. PMID 41473189 · doi:10.3389/fnut.2025.1712993

   Lab simulation of the human gut (not people): about half of a tributyrin dose survived to the colon stage and butyrate levels rose. Funded by a tributyrin supplier.

9. Yang N, et al. Tributyrin alleviates gut microbiota dysbiosis to repair intestinal damage in antibiotic-treated mice. PLoS One. 2023;18(7):e0289364. PMID 37523400 · doi:10.1371/journal.pone.0289364

   Mouse study: tributyrin supported gut barrier markers and microbiome diversity after antibiotics. Animal data only.

10. Depommier C, et al. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nat Med. 2019;25(7):1096-1103. PMID 31263284 · doi:10.1038/s41591-019-0495-2

    Pilot trial, 32 adults with overweight: live and pasteurized Akkermansia were safe and well tolerated for 3 months; most measured changes were with the pasteurized form. Authors hold related patents.

11. Cani PD, et al. Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms. Nat Rev Gastroenterol Hepatol. 2022;19(10):625-637. PMID 35641786 · doi:10.1038/s41575-022-00631-9

    Review of Akkermansia biology and its place among next-generation beneficial microbes.

12. Piercy KL, et al. The Physical Activity Guidelines for Americans. JAMA. 2018;320(19):2020-2028. PMID 30418471 · doi:10.1001/jama.2018.14854

    U.S. guidance: 150+ minutes of moderate activity weekly plus muscle-strengthening on 2+ days.

13. Watson NF, et al. Recommended Amount of Sleep for a Healthy Adult: A Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society. J Clin Sleep Med. 2015;11(6):591-2. PMID 25979105 · doi:10.5664/jcsm.4758

    Expert consensus: adults should regularly sleep 7 or more hours per night.

Studies are cited to explain the science of ingredients and habits. They are not claims that any product will produce a specific result. Individual results vary. Every reference above is a PubMed record, listed with its PMID.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Welcome

Meet Tributyrin Post-Biotic

Butyrate support, designed to arrive further along the digestive tract.

Butyrate is a short-chain fatty acid your gut bacteria make from fiber, and a key fuel for the cells lining your colon. Tributyrin is a stable, odorless way to take it. This guide covers how it works, how to take it, and the food and habits that help your gut routine shine.

At a glance

Per capsule

550 mg tributyrin 55%, yielding 300 mg active tributyrin

Serving

1 capsule daily with food; up to 2 per day

Give it time

At least 4 to 8 weeks of consistent use

Diet

Vegan, gluten-free, non-GMO, dairy-free, nut-free

Bonus

Odorless and stable, unlike sodium butyrate

The science

How tributyrin works

Three butyrate molecules on one backbone, released by digestion.

Meet butyrate

When your gut bacteria ferment fiber, they make short-chain fatty acids, including butyrate [2]. In a classic lab study of human colon cells, butyrate supplied most of the cells' energy when it was available [1], and researchers have since mapped its many roles in the colon, from fuel to the gut barrier [3].

Why tributyrin?

Plain butyrate salts have two practical problems: much of the dose is absorbed early in the digestive tract, and they smell like rancid butter. Tributyrin is three butyrate molecules bound to glycerol. It stays intact until the enzyme lipase releases the butyrate. In a lab model of human digestion, about half of a tributyrin dose remained intact into the colon stage [4]. Results vary by formulation and model, so think of it as a promising delivery approach.

How it may support you*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Practical how-to

How to take it

Five simple steps, straight from the label, to start well.

1. Anchor it to a meal. Take one capsule with breakfast or lunch. Food helps, and it makes the habit easy to remember.
2. Start at one. One capsule a day is the standard serving. You can go up to two per day.
3. Be consistent. Gut routines work on a timescale of weeks. Use it daily for at least 4 to 8 weeks.
4. Feed your microbes too. Tributyrin delivers butyrate directly; fiber helps your own microbes make more (see the food list).
5. Consider a pairing. Many people pair it with our Akkermansia probiotic as a postbiotic and probiotic duo.

Who it is for

• A good fit for: people building a gut-health routine and supporting everyday digestive comfort,* and anyone who tried sodium butyrate but could not get past the smell.
• Check first: with your healthcare provider if you are pregnant, nursing, taking medication, or have a digestive condition.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Food first

Feed your gut: fiber and polyphenols

Supplements work best on top of a plant-rich plate.

Your gut microbes depend on what reaches them. Fiber is their main food, and they turn it into short-chain fatty acids like butyrate [2]. Polyphenols, the colorful compounds in berries, tea and cocoa, also reach the colon, where microbes and polyphenols interact in both directions [5]. Fermented foods add variety: in a 10-week diet study, eating more fermented foods increased gut microbiome diversity [6].

Simple ways to start

• Add, don't subtract. Add one fiber food to a meal you already eat: beans in a salad, berries on oats, flax in a smoothie.
• Go slow. Increase fiber gradually over a few weeks and drink extra water as you do.
• Count your plants. In a large citizen-science study, people eating 30+ different plants a week had more diverse gut microbes than those eating 10 or fewer [7]. Fruits, vegetables, grains, legumes, nuts, seeds and herbs all count.

Daily rhythm

Gut-friendly daily habits

Your gut likes routine. These habits give it a predictable day.

Your weekly plant-count challenge

Each week, tally the different plants you eat. Herbs, spices, nuts and seeds count. Try to beat last week's number.

Putting it together

A sample daily routine

A template, not a rulebook. Shift the times to fit your life.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This sample routine is for general wellness education. Product timing should always follow the label directions. Consult your healthcare provider before starting any supplement, especially if you are pregnant, nursing, taking medication, or managing a health condition.

Track it

Your 30-day checklist

Check off each habit you complete. Aim for progress, not perfection: most days, most habits.

Follow the label directions. Give it at least 4 to 8 weeks.

Evidence notes

How strong is the evidence?

A quick, honest read on how strong the science is for each part of this guide.

How to read the dots: ●●●● strong and consistent human evidence · ●●●○ moderate · ●●○○ early or mixed · ●○○○ mostly lab or animal research.

Worth knowing

• Most tributyrin research is animal or lab-based. We are excited by the science, and honest that human trials in healthy people are still needed.
• Mechanism is not the same as outcome. Knowing butyrate fuels colon cells does not prove a supplement changes how you feel. Notice your own results over weeks.
• Food is the foundation. Fiber, plant variety and fermented foods have the strongest human evidence in this guide.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Evidence notes

What the research suggests

The studies behind this guide, in plain language, with their limits.

1. Roediger WE. Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Gut. 1980;21(9):793-8. PMID 7429343 · doi:10.1136/gut.21.9.793

   Lab study of isolated human colon cells: butyrate was their main fuel when available.

2. Koh A, et al. From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites. Cell. 2016;165(6):1332-1345. PMID 27259147 · doi:10.1016/j.cell.2016.05.041

   Review of how gut microbes turn fiber into short-chain fatty acids such as butyrate.

3. Hamer HM, et al. Review article: the role of butyrate on colonic function. Aliment Pharmacol Ther. 2008;27(2):104-19. PMID 17973645 · doi:10.1111/j.1365-2036.2007.03562.x

   Review of butyrate's roles in the colon, from fuel for colon cells to the gut barrier.

4. Duysburgh C, et al. Tributyrin (CoreBiome®) enhances butyrate levels and modulates the gut microbiota, barrier function, and immune response in vitro. Front Nutr. 2025;12:1712993. PMID 41473189 · doi:10.3389/fnut.2025.1712993

   Lab simulation of the human gut (not people): about half of a tributyrin dose survived to the colon stage and butyrate levels rose. Funded by a tributyrin supplier.

5. Cardona F, et al. Benefits of polyphenols on gut microbiota and implications in human health. J Nutr Biochem. 2013;24(8):1415-22. PMID 23849454 · doi:10.1016/j.jnutbio.2013.05.001

   Review: gut microbes and dietary polyphenols interact in both directions. Human data still limited.

6. Wastyk HC, et al. Gut-microbiota-targeted diets modulate human immune status. Cell. 2021;184(16):4137-4153.e14. PMID 34256014 · doi:10.1016/j.cell.2021.06.019

   Healthy adults: a high-fermented-food diet steadily increased microbiome diversity over 10 weeks. 18 people per group.

7. McDonald D, et al. American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems. 2018;3(3). PMID 29795809 · doi:10.1128/mSystems.00031-18

   Citizen-science study: people eating 30+ different plants a week had more diverse gut microbes than those eating 10 or fewer. Observational.

8. Piercy KL, et al. The Physical Activity Guidelines for Americans. JAMA. 2018;320(19):2020-2028. PMID 30418471 · doi:10.1001/jama.2018.14854

   U.S. guidance: 150+ minutes of moderate activity weekly plus muscle-strengthening on 2+ days.

9. Watson NF, et al. Recommended Amount of Sleep for a Healthy Adult: A Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society. J Clin Sleep Med. 2015;11(6):591-2. PMID 25979105 · doi:10.5664/jcsm.4758

   Expert consensus: adults should regularly sleep 7 or more hours per night.

10. van Deuren T, et al. Butyrate and hexanoate-enriched triglycerides increase postprandrial systemic butyrate and hexanoate in men with overweight/obesity: A double-blind placebo-controlled randomized crossover trial. Front Nutr. 2022;9:1066950. PMID 36687671 · doi:10.3389/fnut.2022.1066950

    In a lab digestion model, plain tributyrin was cleaved early (in the stomach stage). Shows release site depends on formulation. Partly industry-affiliated.

11. Yang N, et al. Tributyrin alleviates gut microbiota dysbiosis to repair intestinal damage in antibiotic-treated mice. PLoS One. 2023;18(7):e0289364. PMID 37523400 · doi:10.1371/journal.pone.0289364

    Mouse study: tributyrin supported gut barrier markers and microbiome diversity after antibiotics. Animal data only.

Studies are cited to explain the science of ingredients and habits. They are not claims that any product will produce a specific result. Individual results vary. Every reference above is a PubMed record, listed with its PMID.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Welcome

Meet Akkermansia

A next-generation probiotic for your gut's protective mucus layer.

Akkermansia muciniphila is a bacterium that naturally lives in the mucus layer lining your gut. It was only described by scientists in 2004 [1], and it has been hard to grow and package, which is why most probiotics leave it out. This guide covers what it does, how to take it, and how to build a gut routine around it.

At a glance

Per capsule

Akkermansia muciniphila, 1 billion AFU (active fluorescent units), microencapsulated

Serving

1 capsule daily with food; up to 2 per day

Give it time

At least 4 to 8 weeks of consistent use

Storage

Shelf-stable at room temperature. No refrigeration needed.

Diet

Vegetarian, gluten-free, dairy-free, nut-free

The science

How Akkermansia works

A specialist that lives in, and helps renew, your gut's mucus layer.

A mucus-layer specialist

Your gut is lined with a layer of mucus that acts as a protective buffer. Akkermansia muciniphila was first isolated from human stool in 2004 and named for its taste for mucin, the main protein in that mucus [1]. By feeding on old mucus, it is thought to help keep the layer renewing, and it is a common member of a healthy gut microbiome [2].

Why "AFU" and not CFU?

Most probiotics count colony-forming units (CFU), which depends on growing bacteria on a lab plate. Akkermansia is notoriously hard to grow that way, so ours is measured in AFU (active fluorescent units), a count of active cells that suits this strain better.

How it may support you*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Practical how-to

How to take it

Five simple steps, straight from the label, to start well.

1. Anchor it to a meal. Take one capsule with breakfast or lunch, every day.
2. Start at one. One capsule is the standard serving; you can go up to two per day.
3. Store it simply. Keep it at room temperature, away from heat and humidity. No fridge needed.
4. Feed it well. Fiber and polyphenol-rich plants feed your whole microbial community (see the food list).
5. Consider a pairing. Akkermansia stacks well with our Tributyrin Post-Biotic as a probiotic and postbiotic duo.

Who it is for

• A good fit for: people building a gut-health routine who want the strain most probiotics leave out, and those pairing a probiotic with a postbiotic.*
• Check first: with your healthcare provider if you are pregnant, nursing, taking medication, immunocompromised, or have a digestive condition.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Food first

Feed your gut: fiber and polyphenols

Supplements work best on top of a plant-rich plate.

Your gut microbes depend on what reaches them. Fiber is their main food, and they turn it into short-chain fatty acids like butyrate [3]. Polyphenols, the colorful compounds in berries, tea and cocoa, also reach the colon, where microbes and polyphenols interact in both directions [4]. Fermented foods add variety: in a 10-week diet study, eating more fermented foods increased gut microbiome diversity [5].

Simple ways to start

• Add, don't subtract. Add one fiber food to a meal you already eat: beans in a salad, berries on oats, flax in a smoothie.
• Go slow. Increase fiber gradually over a few weeks and drink extra water as you do.
• Count your plants. In a large citizen-science study, people eating 30+ different plants a week had more diverse gut microbes than those eating 10 or fewer [6]. Fruits, vegetables, grains, legumes, nuts, seeds and herbs all count.

Daily rhythm

Gut-friendly daily habits

Your gut likes routine. These habits give it a predictable day.

Your weekly plant-count challenge

Each week, tally the different plants you eat. Herbs, spices, nuts and seeds count. Try to beat last week's number.

Putting it together

A sample daily routine

A template, not a rulebook. Shift the times to fit your life.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This sample routine is for general wellness education. Product timing should always follow the label directions. Consult your healthcare provider before starting any supplement, especially if you are pregnant, nursing, taking medication, immunocompromised, or managing a health condition.

Track it

Your 30-day checklist

Check off each habit you complete. Aim for progress, not perfection: most days, most habits.

Follow the label directions. Give it at least 4 to 8 weeks.

Evidence notes

How strong is the evidence?

A quick, honest read on how strong the science is for each part of this guide.

How to read the dots: ●●●● strong and consistent human evidence · ●●●○ moderate · ●●○○ early or mixed · ●○○○ mostly lab or animal research.

Worth knowing

• This is a young field. Akkermansia is one of the most exciting microbes in gut research, and much of the work so far is in animals or small human studies.
• Units differ. The pilot trial used about 10 billion cells a day measured differently from our AFU count, so direct dose comparisons are not possible.
• Researcher interests. The pilot's authors hold related patents and co-founded an Akkermansia company [9]. That is common in early microbiome science.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Evidence notes

What the research suggests

The studies behind this guide, in plain language, with their limits.

1. Derrien M, et al. Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium. Int J Syst Evol Microbiol. 2004;54(Pt 5):1469-1476. PMID 15388697 · doi:10.1099/ijs.0.02873-0

   The original description of Akkermansia muciniphila, a mucin-degrading bacterium isolated from human stool.

2. Cani PD, et al. Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms. Nat Rev Gastroenterol Hepatol. 2022;19(10):625-637. PMID 35641786 · doi:10.1038/s41575-022-00631-9

   Review of Akkermansia biology and its place among next-generation beneficial microbes.

3. Koh A, et al. From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites. Cell. 2016;165(6):1332-1345. PMID 27259147 · doi:10.1016/j.cell.2016.05.041

   Review of how gut microbes turn fiber into short-chain fatty acids such as butyrate.

4. Cardona F, et al. Benefits of polyphenols on gut microbiota and implications in human health. J Nutr Biochem. 2013;24(8):1415-22. PMID 23849454 · doi:10.1016/j.jnutbio.2013.05.001

   Review: gut microbes and dietary polyphenols interact in both directions. Human data still limited.

5. Wastyk HC, et al. Gut-microbiota-targeted diets modulate human immune status. Cell. 2021;184(16):4137-4153.e14. PMID 34256014 · doi:10.1016/j.cell.2021.06.019

   Healthy adults: a high-fermented-food diet steadily increased microbiome diversity over 10 weeks. 18 people per group.

6. McDonald D, et al. American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems. 2018;3(3). PMID 29795809 · doi:10.1128/mSystems.00031-18

   Citizen-science study: people eating 30+ different plants a week had more diverse gut microbes than those eating 10 or fewer. Observational.

7. Piercy KL, et al. The Physical Activity Guidelines for Americans. JAMA. 2018;320(19):2020-2028. PMID 30418471 · doi:10.1001/jama.2018.14854

   U.S. guidance: 150+ minutes of moderate activity weekly plus muscle-strengthening on 2+ days.

8. Watson NF, et al. Recommended Amount of Sleep for a Healthy Adult: A Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society. J Clin Sleep Med. 2015;11(6):591-2. PMID 25979105 · doi:10.5664/jcsm.4758

   Expert consensus: adults should regularly sleep 7 or more hours per night.

9. Depommier C, et al. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nat Med. 2019;25(7):1096-1103. PMID 31263284 · doi:10.1038/s41591-019-0495-2

   Pilot trial, 32 adults with overweight: live and pasteurized Akkermansia were safe and well tolerated for 3 months; most measured changes were with the pasteurized form. Authors hold related patents.

Studies are cited to explain the science of ingredients and habits. They are not claims that any product will produce a specific result. Individual results vary. Every reference above is a PubMed record, listed with its PMID.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Welcome

Stronger, one session at a time

Progressive training, enough protein and real sleep. Supplements support; they do not replace.

Getting stronger is one of the best things you can do for how you feel and move, at any age. This guide gives you a simple training plan, practical protein targets, recovery habits, and an honest look at where PeptiStrong® fits.

The Strength & Recovery collection

PeptiStrong®

2.4 g fava bean (Vicia faba) protein hydrolysate per 4-capsule serving

How to take

4 capsules daily with water, any time; many take them around workouts

Give it time

At least 8 weeks alongside resistance training

Diet

Vegetarian, gluten-free, non-GMO; made in the USA

The foundations

The strength triangle

Train, eat, sleep. Each corner makes the others work.

Why strength matters for everyone

• It is in the guidelines. U.S. guidance recommends muscle-strengthening activity on 2 or more days a week, alongside 150 minutes of moderate activity [4].
• Benefits beyond the gym. Resistance training also improves power, balance, gait speed and everyday physical function [1].
• It is never too late to start. Begin light, learn good form, and progress gradually.

Where supplements fit

Supplements sit on top of the triangle, not inside it. Protein powders can help you reach your daily target, and newer ingredients like PeptiStrong® are designed to support the body's normal muscle-building process when combined with training.*

Formula spotlight

PeptiStrong® Muscle Peptides

A plant-derived peptide network from fava beans, at the full 2.4 g serving.

PeptiStrong® is a patented network of peptides from fava bean protein, identified with AI screening and studied in cells and mice [5, 6]. In a randomized trial of 30 healthy men, 2.4 g a day for two weeks led to better strength recovery over 72 hours after a hard workout [7]. In a second trial, at a much higher daily amount, it matched milk protein for muscle size during recovery from leg immobilization and increased muscle protein synthesis [8]. Both were small and involved the ingredient maker.

PeptiStrong® at a glance

Per serving

2.4 g PeptiStrong® fava bean protein hydrolysate (4 capsules)

How to take

4 capsules daily with water, at any time of day

Give it time

At least 8 weeks with resistance training

Allergen note

Fava bean is a legume. Ask your provider first if you have a legume allergy or G6PD deficiency.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Train smart

Training basics that build strength

Muscle adapts to the work you give it. Here is a simple, proven structure.

A 2026 American College of Sports Medicine position stand, built on 137 systematic reviews, found that progressive resistance training improves strength, muscle size, power and everyday function in healthy adults. Strength responded best to heavier loads, a full range of motion, 2 to 3 sets, and 2+ sessions a week; muscle growth to about 10+ hard sets per week [1].

A simple full-body week

1. Alternate A and B 2 or 3 days a week, with at least one rest day between sessions.
2. Pick a challenging weight Finish each set with 1 to 3 reps "in the tank," with good form.
3. Progress gradually When a set feels easy, add a rep or a little weight next time.
4. Move on off days Walks and light activity count toward the 150 weekly minutes in U.S. guidelines [4].

Fuel

Protein for strength

Your muscles are built between workouts, from the protein you eat and the sleep you get.

How much protein?

An expert position stand suggests 1.4 to 2.0 g of protein per kilogram of body weight per day for most exercising people, ideally spread over meals of about 20 to 40 g [9]. A meta-analysis of 49 trials found that extra protein modestly boosted strength and muscle gains from training, with benefits leveling off around 1.6 g/kg/day [2]. In a lab study, 20 g every 3 hours supported muscle protein synthesis better than fewer, larger servings or many tiny ones [10].

Protein amounts are approximate. If you have kidney disease or another medical condition, ask your healthcare provider what protein intake is right for you.

Recover

Sleep and recovery

The most underrated performance tool is free, and you use it every night.

Sleep matters for muscle. In one study, a single night without sleep lowered muscle protein synthesis by 18% the next day [3]. A systematic review found that several nights of short sleep can reduce strength on big compound lifts [11]. Most adults need 7 or more hours a night [12].

Putting it together

A sample training day

A template, not a rulebook. On rest days, keep the meals, water and sleep the same.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This sample routine is for general wellness education. Product timing should always follow the label directions. Consult your healthcare provider before starting any supplement or new exercise program, especially if you are pregnant, nursing, taking medication, have a legume allergy or G6PD deficiency, or are managing a health condition.

Track it

Your 30-day checklist

Check off each habit you complete. Aim for progress, not perfection: most days, most habits.

*Tick "Strength session" on training days (2 to 3 per week); on rest days, tick it if you rested on purpose. Follow the label directions.

Evidence notes

How strong is the evidence?

A quick, honest read on how strong the science is for each part of this guide.

How to read the dots: ●●●● strong and consistent human evidence · ●●●○ moderate · ●●○○ early or mixed · ●○○○ mostly lab or animal research.

Worth knowing

• The PeptiStrong® studies are largely industry-funded. That is normal for a new branded ingredient, but independent replication is still needed.
• Small and short. The human trials had about 30 participants each, and one used far more than the 2.4 g serving.
• The basics carry the most weight. Progressive training, enough protein and good sleep have the strongest evidence in this guide.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Evidence notes

What the research suggests

The studies behind this guide, in plain language, with their limits.

1. Currier BS, et al. American College of Sports Medicine Position Stand. Resistance Training Prescription for Muscle Function, Hypertrophy, and Physical Performance in Healthy Adults: An Overview of Reviews. Med Sci Sports Exerc. 2026;58(4):851-872. PMID 41843416 · doi:10.1249/MSS.0000000000003897

   2026 ACSM position stand (137 reviews): progressive resistance training 2+ days a week builds strength; about 10+ sets per muscle per week supports muscle growth.

2. Morton RW, et al. A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults. Br J Sports Med. 2018;52(6):376-384. PMID 28698222 · doi:10.1136/bjsports-2017-097608

   Meta-analysis of 49 trials: extra protein modestly boosted strength and muscle gains from resistance training; benefit plateaued around 1.6 g/kg/day.

3. Lamon S, et al. The effect of acute sleep deprivation on skeletal muscle protein synthesis and the hormonal environment. Physiol Rep. 2021;9(1):e14660. PMID 33400856 · doi:10.14814/phy2.14660

   13 young adults: one night without sleep lowered muscle protein synthesis by 18%.

4. Piercy KL, et al. The Physical Activity Guidelines for Americans. JAMA. 2018;320(19):2020-2028. PMID 30418471 · doi:10.1001/jama.2018.14854

   U.S. guidance: 150+ minutes of moderate activity weekly plus muscle-strengthening on 2+ days.

5. Cal R, et al. Preclinical Evaluation of a Food-Derived Functional Ingredient to Address Skeletal Muscle Atrophy. Nutrients. 2020;12(8). PMID 32751276 · doi:10.3390/nu12082274

   Cell and mouse studies of the fava bean hydrolysate behind PeptiStrong. Preclinical, all authors from the ingredient maker.

6. Corrochano AR, et al. Characterising the efficacy and bioavailability of bioactive peptides identified for attenuating muscle atrophy within a Vicia faba-derived functional ingredient. Curr Res Food Sci. 2021;4:224-232. PMID 33937870 · doi:10.1016/j.crfs.2021.03.008

   Lab study identifying the active peptides and how they hold up during digestion. Preclinical, ingredient-maker authors.

7. Kerr A, et al. Improved Strength Recovery and Reduced Fatigue with Suppressed Plasma Myostatin Following Supplementation of a Vicia faba Hydrolysate, in a Healthy Male Population. Nutrients. 2023;15(4). PMID 36839344 · doi:10.3390/nu15040986

   30 healthy men, 2.4 g/day for 14 days: better strength recovery over 72 h after hard exercise vs placebo, not at single time points. Funded and run by the ingredient maker.

8. Weijzen MEG, et al. Vicia faba Peptide Network Supplementation Does Not Differ From Milk Protein in Modulating Changes in Muscle Size During Short-Term Immobilization and Subsequent Remobilization, but Increases Muscle Protein Synthesis Rates During Remobilization in Healthy Young Men. J Nutr. 2023;153(6):1718-1729. PMID 37277162 · doi:10.1016/j.tjnut.2023.01.014

   30 young men, 1 week leg immobilization: no difference vs milk protein in muscle size; higher muscle protein synthesis during recovery. Used 20 g/day. Ingredient-maker co-authors.

9. Jäger R, et al. International Society of Sports Nutrition Position Stand: protein and exercise. J Int Soc Sports Nutr. 2017;14:20. PMID 28642676 · doi:10.1186/s12970-017-0177-8

   Position stand: 1.4 to 2.0 g/kg/day protein for most exercising people, spread across meals of about 20 to 40 g.

10. Areta JL, et al. Timing and distribution of protein ingestion during prolonged recovery from resistance exercise alters myofibrillar protein synthesis. J Physiol. 2013;591(9):2319-31. PMID 23459753 · doi:10.1113/jphysiol.2012.244897

    Small lab study: 20 g of protein every 3 hours supported muscle protein synthesis better than fewer, larger or more frequent smaller doses.

11. Knowles OE, et al. Inadequate sleep and muscle strength: Implications for resistance training. J Sci Med Sport. 2018;21(9):959-968. PMID 29422383 · doi:10.1016/j.jsams.2018.01.012

    Systematic review: several nights of short sleep can reduce strength on big compound lifts.

12. Watson NF, et al. Recommended Amount of Sleep for a Healthy Adult: A Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society. J Clin Sleep Med. 2015;11(6):591-2. PMID 25979105 · doi:10.5664/jcsm.4758

    Expert consensus: adults should regularly sleep 7 or more hours per night.

Studies are cited to explain the science of ingredients and habits. They are not claims that any product will produce a specific result. Individual results vary. Every reference above is a PubMed record, listed with its PMID.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Welcome

Meet PeptiStrong®

A plant-derived peptide network from fava beans, at the full 2.4 g serving.

PeptiStrong® is a patented network of peptides made by breaking down fava bean (Vicia faba) protein. Muscle adapts to training through signals as well as raw materials, and PeptiStrong® is designed to support that process.* This guide shows you how to pair it with the training, protein and sleep habits that matter most.

At a glance

Per serving

2.4 g PeptiStrong® fava bean (Vicia faba) protein hydrolysate (4 capsules)

When

4 capsules daily with water, any time; on training days many people take them around their workout

Give it time

At least 8 weeks, alongside resistance training

Diet

Vegetarian, gluten-free, non-GMO; fava bean is a legume

Bottle

120 capsules, 30 servings

The science

How PeptiStrong® works

Food-derived peptides, discovered with the help of AI.

From fava beans to peptides

Proteins are long chains of amino acids. Break them into shorter pieces and you get peptides, some of which can act as signals in the body. Scientists used AI screening to identify a group of peptides in a fava bean protein hydrolysate, then studied it in cells and mice [2] and tracked how its key peptides hold up during digestion [3].

What the human studies show

In a randomized, placebo-controlled trial of 30 healthy men aged 30 to 45, taking 2.4 g a day for two weeks before a hard workout led to better strength recovery over the following 72 hours, though not at each individual time point [1]. In a second trial, during recovery from a week of leg immobilization, the fava bean peptides matched milk protein for muscle size and led to higher muscle protein synthesis [4]. That study used a much larger daily amount (20 g). Both were small and involved the ingredient maker.

How it may support you*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Practical how-to

How to take it

Five simple steps, straight from the label, to start well.

1. Take all four. The full serving is 4 capsules (2.4 g), the amount used in the strength-recovery study.
2. Pick a time you will remember. Any time of day works. On training days many people take them around their workout.
3. Train for it. PeptiStrong® does the most alongside resistance training 2 to 3 times a week (see the training basics).
4. Keep eating protein. It complements your protein intake rather than replacing it (see protein for strength).
5. Be patient. Give it at least 8 weeks of consistent use before judging results.

Who it is for

• A good fit for: adults who lift or train and want to support strength, endurance and recovery,* and people working to hold on to lean muscle during a cut or a break from training.*
• Check first: fava bean is a legume. If you have a legume allergy or G6PD deficiency, are pregnant or nursing, or take medication, talk to your healthcare provider first.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Train smart

Training basics that build strength

Muscle adapts to the work you give it. Here is a simple, proven structure.

A 2026 American College of Sports Medicine position stand, built on 137 systematic reviews, found that progressive resistance training improves strength, muscle size, power and everyday function in healthy adults. Strength responded best to heavier loads, a full range of motion, 2 to 3 sets, and 2+ sessions a week; muscle growth to about 10+ hard sets per week [5].

A simple full-body week

1. Alternate A and B 2 or 3 days a week, with at least one rest day between sessions.
2. Pick a challenging weight Finish each set with 1 to 3 reps "in the tank," with good form.
3. Progress gradually When a set feels easy, add a rep or a little weight next time.
4. Move on off days Walks and light activity count toward the 150 weekly minutes in U.S. guidelines [6].

Fuel

Protein for strength

Your muscles are built between workouts, from the protein you eat and the sleep you get.

How much protein?

An expert position stand suggests 1.4 to 2.0 g of protein per kilogram of body weight per day for most exercising people, ideally spread over meals of about 20 to 40 g [7]. A meta-analysis of 49 trials found that extra protein modestly boosted strength and muscle gains from training, with benefits leveling off around 1.6 g/kg/day [8]. In a lab study, 20 g every 3 hours supported muscle protein synthesis better than fewer, larger servings or many tiny ones [9].

Protein amounts are approximate. If you have kidney disease or another medical condition, ask your healthcare provider what protein intake is right for you.

Recover

Sleep and recovery

The most underrated performance tool is free, and you use it every night.

Sleep matters for muscle. In one study, a single night without sleep lowered muscle protein synthesis by 18% the next day [10]. A systematic review found that several nights of short sleep can reduce strength on big compound lifts [11]. Most adults need 7 or more hours a night [12].

Putting it together

A sample training day

A template, not a rulebook. Shift the times to fit your life.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This sample routine is for general wellness education. Product timing should always follow the label directions. Consult your healthcare provider before starting any supplement, especially if you are pregnant, nursing, taking medication, have a legume allergy or G6PD deficiency, or are managing a health condition.

Track it

Your 30-day checklist

Check off each habit you complete. Aim for progress, not perfection: most days, most habits.

*Tick "Strength session" on training days (2 to 3 per week); on rest days, tick it if you rested on purpose. Follow the label directions.

Evidence notes

How strong is the evidence?

A quick, honest read on how strong the science is for each part of this guide.

How to read the dots: ●●●● strong and consistent human evidence · ●●●○ moderate · ●●○○ early or mixed · ●○○○ mostly lab or animal research.

Worth knowing

• The PeptiStrong® studies are largely industry-funded. That is normal for a new branded ingredient, but independent replication is still needed.
• Small and short. The human trials had about 30 participants and ran for weeks, not months; the immobilization trial used far more than the 2.4 g serving.
• The basics carry the most weight. Progressive training, enough protein and good sleep have the strongest evidence in this guide.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Evidence notes

What the research suggests

The studies behind this guide, in plain language, with their limits.

1. Kerr A, et al. Improved Strength Recovery and Reduced Fatigue with Suppressed Plasma Myostatin Following Supplementation of a Vicia faba Hydrolysate, in a Healthy Male Population. Nutrients. 2023;15(4). PMID 36839344 · doi:10.3390/nu15040986

   30 healthy men, 2.4 g/day for 14 days: better strength recovery over 72 h after hard exercise vs placebo, not at single time points. Funded and run by the ingredient maker.

2. Cal R, et al. Preclinical Evaluation of a Food-Derived Functional Ingredient to Address Skeletal Muscle Atrophy. Nutrients. 2020;12(8). PMID 32751276 · doi:10.3390/nu12082274

   Cell and mouse studies of the fava bean hydrolysate behind PeptiStrong. Preclinical, all authors from the ingredient maker.

3. Corrochano AR, et al. Characterising the efficacy and bioavailability of bioactive peptides identified for attenuating muscle atrophy within a Vicia faba-derived functional ingredient. Curr Res Food Sci. 2021;4:224-232. PMID 33937870 · doi:10.1016/j.crfs.2021.03.008

   Lab study identifying the active peptides and how they hold up during digestion. Preclinical, ingredient-maker authors.

4. Weijzen MEG, et al. Vicia faba Peptide Network Supplementation Does Not Differ From Milk Protein in Modulating Changes in Muscle Size During Short-Term Immobilization and Subsequent Remobilization, but Increases Muscle Protein Synthesis Rates During Remobilization in Healthy Young Men. J Nutr. 2023;153(6):1718-1729. PMID 37277162 · doi:10.1016/j.tjnut.2023.01.014

   30 young men, 1 week leg immobilization: no difference vs milk protein in muscle size; higher muscle protein synthesis during recovery. Used 20 g/day. Ingredient-maker co-authors.

5. Currier BS, et al. American College of Sports Medicine Position Stand. Resistance Training Prescription for Muscle Function, Hypertrophy, and Physical Performance in Healthy Adults: An Overview of Reviews. Med Sci Sports Exerc. 2026;58(4):851-872. PMID 41843416 · doi:10.1249/MSS.0000000000003897

   2026 ACSM position stand (137 reviews): progressive resistance training 2+ days a week builds strength; about 10+ sets per muscle per week supports muscle growth.

6. Piercy KL, et al. The Physical Activity Guidelines for Americans. JAMA. 2018;320(19):2020-2028. PMID 30418471 · doi:10.1001/jama.2018.14854

   U.S. guidance: 150+ minutes of moderate activity weekly plus muscle-strengthening on 2+ days.

7. Jäger R, et al. International Society of Sports Nutrition Position Stand: protein and exercise. J Int Soc Sports Nutr. 2017;14:20. PMID 28642676 · doi:10.1186/s12970-017-0177-8

   Position stand: 1.4 to 2.0 g/kg/day protein for most exercising people, spread across meals of about 20 to 40 g.

8. Morton RW, et al. A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults. Br J Sports Med. 2018;52(6):376-384. PMID 28698222 · doi:10.1136/bjsports-2017-097608

   Meta-analysis of 49 trials: extra protein modestly boosted strength and muscle gains from resistance training; benefit plateaued around 1.6 g/kg/day.

9. Areta JL, et al. Timing and distribution of protein ingestion during prolonged recovery from resistance exercise alters myofibrillar protein synthesis. J Physiol. 2013;591(9):2319-31. PMID 23459753 · doi:10.1113/jphysiol.2012.244897

   Small lab study: 20 g of protein every 3 hours supported muscle protein synthesis better than fewer, larger or more frequent smaller doses.

10. Lamon S, et al. The effect of acute sleep deprivation on skeletal muscle protein synthesis and the hormonal environment. Physiol Rep. 2021;9(1):e14660. PMID 33400856 · doi:10.14814/phy2.14660

    13 young adults: one night without sleep lowered muscle protein synthesis by 18%.

11. Knowles OE, et al. Inadequate sleep and muscle strength: Implications for resistance training. J Sci Med Sport. 2018;21(9):959-968. PMID 29422383 · doi:10.1016/j.jsams.2018.01.012

    Systematic review: several nights of short sleep can reduce strength on big compound lifts.

12. Watson NF, et al. Recommended Amount of Sleep for a Healthy Adult: A Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society. J Clin Sleep Med. 2015;11(6):591-2. PMID 25979105 · doi:10.5664/jcsm.4758

    Expert consensus: adults should regularly sleep 7 or more hours per night.

Studies are cited to explain the science of ingredients and habits. They are not claims that any product will produce a specific result. Individual results vary. Every reference above is a PubMed record, listed with its PMID.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Welcome

Everyday urinary wellness

Simple habits, steady water, and a daily formula if you want one.

Urinary wellness is something most of us only think about when something feels off. This guide is about the everyday: the hydration and comfort habits with the best research, and an honest look at the ingredients in UroDefend.

The Urinary Health collection

UroDefend

Cranberry extract (12:1) 500 mg, D-mannose 300 mg, pine bark extract 100 mg, vitamin C 100 mg per 2-capsule serving

How to take

2 capsules daily with food

Built for

Women and men

Diet

Vegan, gluten-free, non-GMO; made in the USA

The foundations

How your urinary system works

A quick tour of the system that quietly works all day.

What supports everyday urinary wellness

• Water, spread through the day. This is the habit with some of the best research behind it [2, 1].
• Comfortable bathroom habits. Go when you need to, take your time, and empty fully.
• Whole-body basics. Movement, fiber, and 7+ hours of sleep support how you feel overall [3, 4].
• Knowing your normal. Notice changes in color, comfort or frequency, and check in with a clinician when something feels off (see when to check in).

Formula spotlight

UroDefend

Four well-known ingredients for everyday wellness, in one daily formula.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The #1 habit

Hydration, made easy

Steady water intake is one of the best-researched everyday urinary wellness habits.

A review of the research proposes about 2.5 to 3.5 liters of total water a day for most adults (food supplies some of that), and suggests urine color and how often you go as simple self-checks [1]. In a year-long randomized trial of women who usually drank under 1.5 liters a day, adding 1.5 liters of water daily measurably changed their urinary outcomes [2].

Your urine color check

Some vitamins (especially B vitamins), foods and medications can change urine color. Use this as a rough everyday cue, not a medical test.

A simple daily water plan

If your healthcare provider has asked you to limit fluids (for example, for heart or kidney conditions), follow their advice instead.

Everyday habits

Everyday urinary wellness habits

Small, comfortable habits that support your daily routine.

Your 3-day bladder diary (optional)

Know your signs

When to check in with a clinician

Supplements support everyday wellness. Symptoms deserve real care.

Good questions to ask your provider

• Is my daily water intake right for me, given my health and medications?
• Are there any interactions between my medications and cranberry or other supplements?
• Is there anything specific to my age, pregnancy, or health history I should know?

Special situations

• Pregnancy and breastfeeding: ask your clinician before using any supplement, and report any urinary symptoms promptly.
• Blood thinners and other medications: ask before using cranberry products.
• Fluid limits: if you have been told to limit fluids, follow your provider's advice rather than general water targets.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Putting it together

A sample daily routine

A template, not a rulebook. Shift the times to fit your life.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This sample routine is for general wellness education. Product timing should always follow the label directions. Consult your healthcare provider before starting any supplement, especially if you are pregnant, breastfeeding, taking medication (including blood thinners), or managing a health condition.

Track it

Your 30-day checklist

Check off each habit you complete. Aim for progress, not perfection: most days, most habits.

Follow the label directions. If you notice urinary symptoms, contact your healthcare provider.

Evidence notes

How strong is the evidence?

A quick, honest read on how strong the science is for each part of this guide.

How to read the dots: ●●●● strong and consistent human evidence · ●●●○ moderate · ●●○○ early or mixed · ●○○○ mostly lab or animal research.

Worth knowing

• We say "mixed" on purpose. Cranberry and D-mannose studies used different products, doses and groups, and their results disagree. Many used 2 g of D-mannose; UroDefend has 300 mg.
• None of these studies tested UroDefend. They describe ingredients, not our formula, and they are not a promise of any result.
• Water is the standout habit. It is free, simple and good for the whole body.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Evidence notes

What the research suggests

The studies behind this guide, in plain language, with their limits.

1. Perrier ET, et al. Hydration for health hypothesis: a narrative review of supporting evidence. Eur J Nutr. 2021;60(3):1167-1180. PMID 32632658 · doi:10.1007/s00394-020-02296-z

   Review: proposes about 2.5 to 3.5 L total water a day for most adults; urine color is a simple self-check. Authors linked to a water company.

2. Hooton TM, et al. Effect of Increased Daily Water Intake in Premenopausal Women With Recurrent Urinary Tract Infections: A Randomized Clinical Trial. JAMA Intern Med. 2018;178(11):1509-1515. PMID 30285042 · doi:10.1001/jamainternmed.2018.4204

   Randomized trial in 140 women who drank under 1.5 L/day: adding 1.5 L of water daily changed urinary outcomes over 12 months. Some authors from a water company.

3. Piercy KL, et al. The Physical Activity Guidelines for Americans. JAMA. 2018;320(19):2020-2028. PMID 30418471 · doi:10.1001/jama.2018.14854

   U.S. guidance: 150+ minutes of moderate activity weekly plus muscle-strengthening on 2+ days.

4. Watson NF, et al. Recommended Amount of Sleep for a Healthy Adult: A Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society. J Clin Sleep Med. 2015;11(6):591-2. PMID 25979105 · doi:10.5664/jcsm.4758

   Expert consensus: adults should regularly sleep 7 or more hours per night.

5. Williams G, et al. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2023;11(11):CD001321. PMID 37947276 · doi:10.1002/14651858.CD001321.pub7

   Cochrane review, 50 trials: cranberry products probably helped some groups, with little or no benefit in others. Results vary by population and product.

6. Weichmann F, et al. Pycnogenol® French maritime pine bark extract in randomized, double-blind, placebo-controlled human clinical studies. Front Nutr. 2024;11:1389374. PMID 38757130 · doi:10.3389/fnut.2024.1389374

   Review of 39 placebo-controlled trials of one branded French maritime pine bark extract; antioxidant activity among its studied properties. Author employed by the brand owner.

7. Carr AC, et al. Vitamin C and Immune Function. Nutrients. 2017;9(11). PMID 29099763 · doi:10.3390/nu9111211

   Review: vitamin C is an essential antioxidant nutrient that supports normal immune function.

8. Kranjčec B, et al. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014;32(1):79-84. PMID 23633128 · doi:10.1007/s00345-013-1091-6

   308 women: earlier single-center trial with a positive result for 2 g/day D-mannose; not placebo-controlled.

9. Cooper TE, et al. D-mannose for preventing and treating urinary tract infections. Cochrane Database Syst Rev. 2022;8(8):CD013608. PMID 36041061 · doi:10.1002/14651858.CD013608.pub2

   Cochrane review, 7 small trials: too little high-quality evidence to support or refute D-mannose.

10. Hayward G, et al. d-Mannose for Prevention of Recurrent Urinary Tract Infection Among Women: A Randomized Clinical Trial. JAMA Intern Med. 2024;184(6):619-628. PMID 38587819 · doi:10.1001/jamainternmed.2024.0264

    Large UK trial, 598 women, 2 g/day for 6 months: D-mannose did not outperform placebo for the outcome studied. No conflicts reported.

Studies are cited to explain the science of ingredients and habits. They are not claims that any product will produce a specific result. Individual results vary. Every reference above is a PubMed record, listed with its PMID.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Welcome

Meet UroDefend

Four well-known ingredients for everyday wellness, in one daily formula.

Many people drink cranberry juice out of habit, but juice brings plenty of sugar along with the fruit. UroDefend uses a concentrated 12:1 cranberry extract instead, rounded out with D-mannose, pine bark extract and vitamin C. This guide explains each ingredient and the daily habits, especially hydration, that make a wellness routine work.

At a glance

Per serving

Cranberry extract (12:1) 500 mg, D-mannose 300 mg, pine bark extract 100 mg, vitamin C (as ascorbic acid) 100 mg

Serving

2 capsules daily with food

Built for

Women and men

Diet

Vegan, gluten-free, non-GMO

Bottle

60 capsules, 30 servings

The ingredients

What is inside UroDefend

Four ingredients, each with a clear job in your daily routine.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Practical how-to

How to take it

Five simple steps, straight from the label, to start well.

1. Take two with a meal. Two capsules daily with food. Breakfast or lunch makes it easy to remember.
2. Drink a full glass of water. Use your capsule time as a cue to drink, and keep going through the day (see the water plan).
3. Be consistent. UroDefend is designed as a daily habit, not an occasional fix.
4. Skip the juice. The extract gives you cranberry without the sugar, so there is no need for sweetened juice.
5. Check in first if needed. Ask your clinician before use if you are pregnant, breastfeeding or taking medication.

Who it is for

• A good fit for: adults who want a simple daily wellness habit,* and anyone who has been drinking cranberry juice out of habit and wants the fruit extract without the sugar.
• Check first: with your healthcare provider if you are pregnant, breastfeeding, take medication (cranberry products may interact with some, such as the blood thinner warfarin), or manage a health condition.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The #1 habit

Hydration, made easy

Steady water intake is one of the best-researched everyday urinary wellness habits.

A review of the research proposes about 2.5 to 3.5 liters of total water a day for most adults (food supplies some of that), and suggests urine color and how often you go as simple self-checks [4]. In a year-long randomized trial of women who usually drank under 1.5 liters a day, adding 1.5 liters of water daily measurably changed their urinary outcomes [5].

Your urine color check

Some vitamins (especially B vitamins), foods and medications can change urine color. Use this as a rough everyday cue, not a medical test.

A simple daily water plan

If your healthcare provider has asked you to limit fluids (for example, for heart or kidney conditions), follow their advice instead.

Everyday habits

Everyday urinary wellness habits

Small, comfortable habits that support your daily routine.

Putting it together

A sample daily routine

A template, not a rulebook. Shift the times to fit your life.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This sample routine is for general wellness education. Product timing should always follow the label directions. Consult your healthcare provider before starting any supplement, especially if you are pregnant, breastfeeding, taking medication (including blood thinners), or managing a health condition.

Track it

Your 30-day checklist

Check off each habit you complete. Aim for progress, not perfection: most days, most habits.

Follow the label directions. If you notice urinary symptoms, contact your healthcare provider.

Evidence notes

How strong is the evidence?

A quick, honest read on how strong the science is for each part of this guide.

How to read the dots: ●●●● strong and consistent human evidence · ●●●○ moderate · ●●○○ early or mixed · ●○○○ mostly lab or animal research.

Worth knowing

• We say "mixed" on purpose. Cranberry and D-mannose studies used different products, doses and groups of people, and their results disagree. Many used 2 g of D-mannose; UroDefend has 300 mg.
• None of these studies tested UroDefend. They describe the ingredients, not our formula, and they are not a promise of any specific result.
• Hydration is the habit with the clearest everyday payoff. It is free, simple, and good for the whole body.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Evidence notes

What the research suggests

The studies behind this guide, in plain language, with their limits.

1. Williams G, et al. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2023;11(11):CD001321. PMID 37947276 · doi:10.1002/14651858.CD001321.pub7

   Cochrane review, 50 trials: cranberry products probably helped some groups, with little or no benefit in others. Results vary by population and product.

2. Weichmann F, et al. Pycnogenol® French maritime pine bark extract in randomized, double-blind, placebo-controlled human clinical studies. Front Nutr. 2024;11:1389374. PMID 38757130 · doi:10.3389/fnut.2024.1389374

   Review of 39 placebo-controlled trials of one branded French maritime pine bark extract; antioxidant activity among its studied properties. Author employed by the brand owner.

3. Carr AC, et al. Vitamin C and Immune Function. Nutrients. 2017;9(11). PMID 29099763 · doi:10.3390/nu9111211

   Review: vitamin C is an essential antioxidant nutrient that supports normal immune function.

4. Perrier ET, et al. Hydration for health hypothesis: a narrative review of supporting evidence. Eur J Nutr. 2021;60(3):1167-1180. PMID 32632658 · doi:10.1007/s00394-020-02296-z

   Review: proposes about 2.5 to 3.5 L total water a day for most adults; urine color is a simple self-check. Authors linked to a water company.

5. Hooton TM, et al. Effect of Increased Daily Water Intake in Premenopausal Women With Recurrent Urinary Tract Infections: A Randomized Clinical Trial. JAMA Intern Med. 2018;178(11):1509-1515. PMID 30285042 · doi:10.1001/jamainternmed.2018.4204

   Randomized trial in 140 women who drank under 1.5 L/day: adding 1.5 L of water daily changed urinary outcomes over 12 months. Some authors from a water company.

6. Piercy KL, et al. The Physical Activity Guidelines for Americans. JAMA. 2018;320(19):2020-2028. PMID 30418471 · doi:10.1001/jama.2018.14854

   U.S. guidance: 150+ minutes of moderate activity weekly plus muscle-strengthening on 2+ days.

7. Watson NF, et al. Recommended Amount of Sleep for a Healthy Adult: A Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society. J Clin Sleep Med. 2015;11(6):591-2. PMID 25979105 · doi:10.5664/jcsm.4758

   Expert consensus: adults should regularly sleep 7 or more hours per night.

8. Kranjčec B, et al. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014;32(1):79-84. PMID 23633128 · doi:10.1007/s00345-013-1091-6

   308 women: earlier single-center trial with a positive result for 2 g/day D-mannose; not placebo-controlled.

9. Cooper TE, et al. D-mannose for preventing and treating urinary tract infections. Cochrane Database Syst Rev. 2022;8(8):CD013608. PMID 36041061 · doi:10.1002/14651858.CD013608.pub2

   Cochrane review, 7 small trials: too little high-quality evidence to support or refute D-mannose.

10. Hayward G, et al. d-Mannose for Prevention of Recurrent Urinary Tract Infection Among Women: A Randomized Clinical Trial. JAMA Intern Med. 2024;184(6):619-628. PMID 38587819 · doi:10.1001/jamainternmed.2024.0264

    Large UK trial, 598 women, 2 g/day for 6 months: D-mannose did not outperform placebo for the outcome studied. No conflicts reported.

Studies are cited to explain the science of ingredients and habits. They are not claims that any product will produce a specific result. Individual results vary. Every reference above is a PubMed record, listed with its PMID.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.