Randomized human crossover trial: blood levels
d9-caffeine vs caffeine: how long it stays in the blood
Sherman et al. · Regulatory Toxicology and Pharmacology · 2022
- Study design
- 20 healthy adults · one dose of caffeine (50 mg or 250 mg) or a matched amount of d9-caffeine, taken as a drink · blood sampled for 48 hours
- What it found
- d9-caffeine reached a somewhat higher peak and about 4 to 5 times the total blood exposure of regular caffeine, with much lower levels of caffeine’s active breakdown products. Both were well tolerated.



